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Vegan and vegetarian athletes almost certainly need supplementation, as do those over 50 whose absorption naturally declines

But our other recommendations are effective in their own rights

Because PPIs are sensitive to degradation by strong acid, they have a limited half life within the acidic canaliculi, which can lead to less than maximal effect during the first ~3 days of therapy, and inadequate elevation of gastric pH without repetitive dosing

Uremia and chronic kidney disease: the role of the gut microflora and therapies with pro- and prebiotics

The monitored parameters were insulin requirement, C peptide, blood glucose and HbA1c